Treatment of depression – pharmacotherapy, psychotherapy, support of relatives

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Medical advances have also developed treatments for depression. Previous measures – diet, bloodletting, electroshock, and lobotomy – are gradually becoming a thing of the past today. Currently, the treatment of depression is based on antidepressants, psychotherapy, participation in support groups, use of sleep deprivation (total or partial sleep deprivation), and sometimes electroconvulsive therapy. In patients with atypical depression (where typical symptoms of depression may be masked by symptoms from various systems and organs), the factor that caused the disease should also be eliminated.


Operations (lobotomies), which began in the 1940s, were abandoned due to serious complications (often including deaths). A new chapter in the treatment of depressive disorders began with the introduction of antidepressants to therapy. Along with gaining knowledge about the nature of the disease, scientists developed new drugs that are now the standard of care for endogenous depression. If you are afraid of pharmacotherapy you can try other methods like TMS Therapy combined with psychoterapy. More information you will find on website
The task of antidepressants is to improve the patient’s mood, reduce anxiety and anxiety, reduce sleep disorders, and improve thought and movement processes. The substances contained in these preparations improve the functioning of mediators – serotonin and noradrenaline – whose disorders are responsible for depression. Most of them inhibit the reuptake of norepinephrine and serotonin from the synaptic clefts into the nerve cells. The result is an increase in the concentration of these hormones in neurons and an improvement in their functioning.

Antidepressants and Pain

Some antidepressants are powerful weapons against chronic pain, even in people without depression. This applies to the treatment of chronic and neuropathic pain. This property and application concerns mainly TLPDs – tricyclic antidepressants (e.g. amitriptyline, clomipramine, imipramine). Newer drugs, such as SSNRIs, ie selective serotonin and norepinephrine reuptake inhibitors (e.g. venlafaxine) can also be effective, although less than TLPDs. Popular SSRIs, i.e. selective serotonin uptake inhibitors (e.g. paroxetine, fluoxetine) do not seem to have such an effect. It is not entirely clear how these drugs work to reduce pain sensation. It is possible that by increasing the concentration of neuronal transmitters in the spinal cord, they block the transmission of pain stimuli.


There are many different approaches that have specific therapeutic methods. The most important thing in psychotherapy, however, is that it allows patients to recover faster and strengthens the effects of pharmacotherapy. As you know, treating depression is more effective if the patient believes in its results and is strongly motivated to improve their health. Working with a depressed person is very difficult because their understanding of the world is distorted. Such people do not see any sense in their further existence, their life so far, as well as their future, appear in dark colors. This often causes resistance to self-insight and problems. Depression is a disease of the soul, so in addition to treating the body, it is also worth taking care of the mental condition of a sick person.

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